Daniel A. Fletcher Associate Professor, Department of Bioengineering Faculty Scientist, Lawrence Berkeley National Laboratory Deputy Division Director, Physical Biosciences Division, LBL 608B Stanley Hall mailcode: 1762 (510) 643-5624 fax: (510) 642-5835 This e-mail address is being protected from spambots. You need JavaScript enabled to view it http://fletchlab.berkeley.edu

Joined the UC Berkeley Faculty in 2002

Research Interests

My laboratory studies the mechanics and dynamics of cell movements on the purified protein, single cell, and tissue levels.  For these studies, we are developing new instruments to quantify cell and molecular mechanics based on optical microscopy, force microscopy, and microfabrication.

Education

2002    Postdoctoral Fellow, Stanford University, Biochemistry
2001    Ph.D., Stanford University, Mechanical Engineering
1997    D.Phil., Oxford University, Engineering Science
1994    B.S.E., Princeton University, Mechanical & Aerospace Engineering

Major Awards

2008-2009   White House Fellow, Washington, DC
2008           Vodafone Wireless Innovation Challenge
2008           Intel Inspire-Empower Challenge
2005           Hellman Faculty Fund Award, UC Berkeley
2004           National Science Foundation CAREER Award
2004           National Collegiate Inventors and Innovators E-Team Award
2003           UC Berkeley Presidential Chair Fellow
2001           National Inventors Hall of Fame Collegiate Inventors Award
1996           National Science Foundation Graduate Research Fellowship
1995           American Society of Mechanical Engineering Arthur L. Williston Medal
1994           Rhodes Scholarship

Professional Experience

2007-present    Deputy Division Director, Physical Biosciences, Lawrence Berkeley National Lab
2007-present    Associate Professor, Bioengineering, UC Berkeley  
2002-2007        Assistant Professor, Bioengineering, UC Berkeley
2003-present    Faculty Scientist, Physical Biosciences, Lawrence Berkeley National Laboratory
2003-present    Member, Nanoscale Science & Engineering Graduate Group, UC Berkeley
2002-present    Member, Bioengineering Graduate Group, UC Berkeley & UCSF
2002-present    Member, Biophysics Graduate Group, UC Berkeley
2002-present    Faculty Affiliate, QB3, UC Berkeley

Selected Publications

D.N. Breslauer, R.N. Maamari, N.A. Switz, W.A. Lam, D.A. Fletcher, "Mobile Phone Based Clinical Microscopy for Global Health Applications", PLoS ONE 4(7): e6320, 2009.

D.A. Fletcher and P.L. Geissler, "Active biological materials", Annual Review of Physical Chemistry, vol. 60, 469-486, 2009.

J.C. Stachowiak, T.H. Li, A. Arora, S. Mitragotri, D.A. Fletcher, "Dynamic control of needle-free jet injection", J. Control Release, vol. 135(2), 104-112, April 2009.

O. Chaudhuri, S.H. Parekh, W.A. Lam, D.A. Fletcher, "Combined atomic force microscopy and side-view optical imaging for mechanical studies of cells", Nature Methods, vol. 6(5), 383-387, May 2009.

M.J. Rosenbluth, A. Crow, J.W. Shaevitz, D.A. Fletcher, "Slow Stress Propagation in Adherent Cells" Biophysical J vol. 95, 6052-6059, December 2008.

S.C. Hsiao, A.K. Crow, W.A. Lam, C.R. Bertozzi, D.A. Fletcher, M.B. Francis, "DNA-coated AFM cantilevers for the investigation of cell adhesion and the patterning of live cells" Angew Chem Int Ed Engl vol. 47, 8473-8477, 2008.

A.P. Liu, D.L. Richmond, L. Maibaum, S. Pronk, P.L. Geissler, D.A. Fletcher, "Membrane-induced bundling of actin filaments", Nature Physics vol. 4, 789-793, October 2008.

S. Pronk, P.L. Geissler, D.A. Fletcher, "Limits of filipodium stability" Phys Rev Lett vol. 100, 258102, June 2008.

M.J. Rosenbluth, W.A. Lam, D.A. Fletcher, "Analyzing cell mechanics in hematologic diseases with microfluidic biophysical flow cytometry" Lab Chip vol. 8, 1062-1070, July 2008.

J.W. Shaevitz, D.A. Fletcher, "Curvature and torsion in growing actin networks" Phys Biol vol. 5, 26006, June 2008.

W.A. Lam, M.J. Rosenbluth, D.A. Fletcher, "Increased leukaemia cell stiffness is associated with symptoms of leucostasis in paediatric acute lymphoblastic leukaemia" Br J Haematol vol. 142, 480-501, June 2008.

J.C. Stachowiak, D.L. Richmond, T.H. Li, A.P. Liu, S.H. Parekh, D.A. Fletcher, "Unilamellar vesicle formation and encapsulation by microfluidic jetting" PNAS, vol. 105, 4697-702, March 2008.

W.R. Hansen, D.A. Fletcher, "Tonic shock induces detachment of Giardia lamblia" PLoS Negl Trop Dis. 2008 Feb;2(2):e169.